Anti-MRE11 Antibody, clone 8Q2B3, Rabbit Monoclonal

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

A synthetic peptide corresponding to a sequence within amino acids 400-500 of human MRE11 (P49959).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB,ChIP