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SAB5702616

Sigma-Aldrich

Anti-OPRD1 Antibody, clone 1R4W8, Rabbit Monoclonal

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Synonym(s):
OPRD

biological source

rabbit

Quality Level

100

material

colorless

clone

1R4W8, monoclonal

form

liquid

mol wt

45 kDa

species reactivity

rat, human, rat

concentration

1.1 mg/mL

technique(s)

western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATS

UniProt accession no.

P41143

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OPRD1(4985)

General description

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OPRD1 (P41143).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Information

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