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Merck
CN

SAB5702957

Anti-NKX2-1 Antibody, clone 3O2N3, Rabbit Monoclonal

Synonym(s):

BCH, BHC, NK-2, NKX2.1, NKX2A, NMTC1, T/EBP, TEBP, TITF1, TTF-1, TTF1

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About This Item

NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
3O2N3, monoclonal
Application:
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
rat, human, rat
Citations:
Technique(s):
immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:500 - 1:1000
western blot: 1:500 - 1:2000
Uniprot accession no.:
P43699

Key Documents

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biological source

rabbit

conjugate

unconjugated

material

colorless

clone

3O2N3, monoclonal

form

liquid

mol wt

42 kDa

species reactivity

rat, human, rat

concentration

0.33 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:500 - 1:1000
western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPY

UniProt accession no.

P43699

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... NKX2-1(7080)

Application

WB, IHC, IF/ICC

General description

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX2-1 (P43699).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Information

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