SAB5702998
Anti-UPF1/RENT1 Antibody, clone 5D5C4, Rabbit Monoclonal
Synonym(s):
HUPF1, NORF1, RENT1, pNORF1, smg-2
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5D5C4, monoclonal
Application:
IF, IP, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
5D5C4, monoclonal
form
liquid
mol wt
140 kDa
concentration
0.4mg/ml
technique(s)
immunofluorescence: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAGGPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UPF1(5976)
species reactivity
human
General description
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UPF1/RENT1 (Q92900).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB,IF/ICC, IP
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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