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Merck
CN

SAB6010050

Sigma-Aldrich

Anti-phospho-FOXO3 (S253) antibody, clone 1E1, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

Synonym(s):

Forkhead box protein O3, AF6q21 protein, FOXO3

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About This Item

UNSPSC Code:
12352203

Key Documents

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recombinant

expressed in HEK 293 F cells

Quality Level

100

conjugate

unconjugated

antibody product type

primary antibodies

clone

1E1, recombinant monoclonal

form

liquid

mol wt

150 kDa

purified by

affinity chromatography

species reactivity

human

concentration

0.8mg/ml

technique(s)

ELISA: 2000:10000
flow cytometry: 1:50-1:200
immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200

isotype

IgG

UniProt accession no.

O43524

shipped in

wet ice

storage temp.

-10 to -25°C

target post-translational modification

phosphorylation (pSer253)

General description

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5′-[AG]TAAA[TC]A-3′. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3′UTR of MYC transcript and prevent its translation.

Immunogen

A synthesized peptide derived from human Phospho-FOXO3 (S253)

Physical form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preparation Note

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Other Notes

AV-pS-MD

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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