SAB6010071
Anti-phospho-GSK3A/GSK3B (Y216 + Y279) antibody, clone 4A5, Rabbit Monoclonal
recombinant, expressed in HEK293F cells
Synonym(s):
Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4A5, recombinant monoclonal
Application:
ELISA, FACS, IF, IHC
Citations:
-
recombinant
expressed in HEK 293 F cells
Quality Segment
conjugate
unconjugated
antibody product type
primary antibodies
clone
4A5, recombinant monoclonal
form
liquid
mol wt
150 kDa
purified by
affinity chromatography
species reactivity
human
concentration
0.6mg/ml
technique(s)
ELISA: 2000:10000, flow cytometry: 1:50-1:200, immunofluorescence: 1:50-1:200, immunohistochemistry: 1:50-1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
-10 to -25°C
target post-translational modification
phosphorylation (pTyr216 + pTyr279)
General description
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Immunogen
A synthesized peptide derived from human Phospho-GSK3A/GSK3B (Y216 + Y279)
Physical form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Other Notes
VS-pY-IS
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Storage Class
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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