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Merck
CN

SAB6012030

Anti CDC6 Antibody, clone 23GB3410, Rabbit Monoclonal

newenhanced validation

clone 23GB3410, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

CDC18L, HsCDC18, HsCDC6, MGORS5

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB3410, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

63 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

1 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000094804

NCBI accession no.

NP_001245.1

UniProt accession no.

Q99741

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDC6(990)

General description

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 1-54 of human Cdc6 [NP_001245.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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