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Merck
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SAB6012042

Anti Activating transcription factor 1 Antibody, clone 23GB4325, Rabbit Monoclonal

newenhanced validation

clone 23GB4325, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

EWS-ATF1, FUS/ATF-1, TREB36

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB4325, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

29 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.537 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000123268

NCBI accession no.

NP_005162.1

UniProt accession no.

P18846

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATF1(466)

General description

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 200-271 of human ATF1 [NP_005162.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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