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Merck
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SAB6012107

Anti Histone deacetylase 8 Antibody, clone 23GB6185, Rabbit Monoclonal

newenhanced validation

clone 23GB6185, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

CDA07, CDLS5, HDACL1, KDAC8, MRXS6

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB6185, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

42 kDa

species reactivity

human, rat

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.296 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000147099

NCBI accession no.

NP_001159890.1

UniProt accession no.

Q9BY41

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HDAC8(55869)

General description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 45-103 of human HDAC8 [NP_001159890.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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