Anti PTPN1/PTPN2 Antibody, clone 24GB1130, Rabbit Monoclonal
clone 24GB1130, recombinant rabbit monoclonal, expressed in HEK293 cells
Sustainability features
Enhanced Validation
Synonym(s):
PTP1B, PTPT, TC-PTP, TC45
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About This Item
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
24GB1130, recombinant monoclonal
Application:
FACS, WB
Citations:
-
biological source
rabbit (Monoclonal)
Quality Segment
recombinant
expressed in HEK 293 cells
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
24GB1130, recombinant monoclonal
form
buffered aqueous glycerol solution
mol wt
50,48 kDa
species reactivity
human, rat
packaging
vial of 1.5 mL
enhanced validation
recombinant expression
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sustainability
Sustainability features
concentration
0.5 mg/ml
technique(s)
flow cytometry: 1:2000, western blot: 1:1,000-1:5,000
isotype
IgG
Ensembl | human accession no.
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Click here to view its product sustainability scorecard.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]/The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Immunogen
A synthesized peptide corresponding to a sequence within amino acids 11-66 of human PTPN1/2 [NP_002819.2].
Physical form
Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
Other Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
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Storage Class
10 - Combustible liquids
Flash Point (°F)
572.0 °F
Flash Point (°C)
300 °C
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