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Merck
CN

SAB6012192

Anti Desmocollin 3 Antibody, clone 23GB1200, Rabbit Monoclonal

newenhanced validation
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clone 23GB1200, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

CDHF3, DSC1, DSC2, DSC4

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB1200, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

100 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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sustainability

Greener Alternative Product

concentration

0.4 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000134762

NCBI accession no.

NP_077740.1

UniProt accession no.

Q14574

greener alternative category

DfS-Developed

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DSC3(1825)

Related Categories

General description

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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Immunogen

A synthesized peptide corresponding to a sequence within amino acids 840-896 of Desmocollin 3 [NP_077740.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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Regulatory Information

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