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Merck
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SAB6012283

KD-Validated Anti Carbamoyl-phosphate synthase 1 Antibody, clone 23GB2365, Rabbit Monoclonal

newenhanced validation

clone 23GB2365, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

CPSASE1, CPSase I, GATD6, PHN

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB2365, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

165 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.325 mg/ml

technique(s)

immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000021826

NCBI accession no.

NP_001116105.1

UniProt accession no.

P31327

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CPS1(1373)

General description

The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 100-166 of human CPS1 [NP_001116105.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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