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Merck
CN

SAB6012364

KD-Validated Anti Cytoplasmic FMR1 interacting protein 1 Antibody, clone 23GB1605, Rabbit Monoclonal

newenhanced validation

clone 23GB1605, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

KIAA, P140SRA-1, SRA1

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB1605, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

145 kDa

species reactivity

rat, human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.5 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000273749

NCBI accession no.

NP_055423.1

UniProt accession no.

Q7L576

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CYFIP1(23191)

General description

This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, Mar 2022]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 50-100 of human CYFIP1 [NP_055423.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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