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Merck
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SAB6012382

KD-Validated Anti GEMIN2 Antibody, clone 23GB5835, Rabbit Monoclonal

newenhanced validation

clone 23GB5835, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

Gemin-2, SIP1

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About This Item

UNSPSC Code:
12352203

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB5835, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

32 kDa

species reactivity

rat, human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.5 mg/ml

technique(s)

flow cytometry: 1:2000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000092208

NCBI accession no.

NP_001009182.1

UniProt accession no.

O14893

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GEMIN2(8487)

General description

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 11-71 of human Gemin 2 [NP_001009182.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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