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Merck
CN

SAB6012397

KD-Validated Anti Mevalonate Kinase Antibody, clone 24GB115, Rabbit Monoclonal

newenhanced validation

clone 24GB115, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

LRBP, MK, MVLK, POROK3

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About This Item

UNSPSC Code:
12352203
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biological source

rabbit (Monoclonal)

Quality Level

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

24GB115, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

42 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

0.2 mg/ml

technique(s)

immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MVK(4598)

General description

This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 320-370 of human MVK [NP_000422.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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Regulatory Information

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