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Merck
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SAB6012401

KD-Validated Anti Metastasis Associated 1 Family Member 2 Antibody, clone 24GB400, Rabbit Monoclonal

newenhanced validation

clone 24GB400, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

MTA1L1, PID

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

24GB400, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

75 kDa

species reactivity

human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

0.8 mg/ml

technique(s)

flow cytometry: 1:2000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000149480

NCBI accession no.

NP_004730.2

UniProt accession no.

O94776

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTA2(9219)

General description

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 600-668 of human MTA2 [NP_004730.2].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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