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Merck
CN

SAB6012492

KD-Validated Anti NF2 / Merlin Antibody, clone 23GB2620, Rabbit Monoclonal

newenhanced validation

clone 23GB2620, recombinant rabbit monoclonal, expressed in HEK293 cells

Synonym(s):

BANF, MERLIN, SCH, SWNV

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit (Monoclonal)

Quality Level

100

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

23GB2620, recombinant monoclonal

form

buffered aqueous glycerol solution

mol wt

70 kDa

species reactivity

rat, human

packaging

vial of 1.5 mL

enhanced validation

recombinant expression
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concentration

0.35 mg/ml

technique(s)

flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000

isotype

IgG

Ensembl | human accession no.

ENSG00000186575

NCBI accession no.

NP_000259.1

UniProt accession no.

P35240

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NF2(4771)

General description

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein′s function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 550-595 of human NF2 / Merlin [NP_000259.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

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