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SBNMQ

NMQ/N-methyl-quinidine - MDR1/P-gp Substrate

Name: NMQ/N-methyl-quinidine - MDR1/P-gp Substrate
Brand: SIGMA

Synonym(s):

SB-NMQ, N-methyl-quinidine (NMQ), NMQ

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₇IN₂O₂

CAS Number:

42982-87-6

Molecular Weight:

466.36

UNSPSC Code:

12352200

NACRES:

NA.84

Form:

powder

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Properties

form

powder

color

white

storage temp.

room temp

SMILES string

[I-].[N+]21([C@H](CC([C@H](C2)C=C)CC1)[C@@H](O)c3c4c(ncc3)ccc(c4)OC)C

InChI

1S/C21H27N2O2.HI/c1-4-14-13-23(2)10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-3)12-18(17)19;/h4-7,9,12,14-15,20-21,24H,1,8,10-11,13H2,2-3H3;1H/q+1;/p-1/t14-,15?,20+,21-,23?;/m0./s1

InChI key

AJQSDVGBERUTGX-QVEQJUGRSA-M

Description

Application

NMQ/N-methyl-quinidine - MDR1/P-gp substrate has been used as a probe substrate for multidrug resistance protein 1 (MDR1) in vesicles assay.

Biochem/physiol Actions

SOLVO Biotechnology offers NMQ as a selective substrate for the MDR1 membrane transporter.

NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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