SBR00043
PK150
Sorafenib analog
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关于此项目
经验公式（希尔记法）:
C15H8ClF5N2O3
化学文摘社编号:
分子量:
394.68
UNSPSC Code:
51112008
NACRES:
NA.76
MDL number:
Quality Segment
form
powder
antibiotic activity spectrum
Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
FC1(Oc2c(ccc(c2)NC(=O)Nc3cc(c(cc3)Cl)C(F)(F)F)O1)F
InChI
1S/C15H8ClF5N2O3/c16-10-3-1-7(5-9(10)14(17,18)19)22-13(24)23-8-2-4-11-12(6-8)26-15(20,21)25-11/h1-6H,(H2,22,23,24)
InChI key
SHPYXCLUNMOJOB-UHFFFAOYSA-N
General description
PK150 is a recently discovered small antimicrobial compound. It is a potent analog of sorafenib, an anticancer drug. PK150 has structural similarity with triclocarban (TCC) and triclosan (TCS) with a N,N′-diaryl urea motif in common.
Biochem/physiol Actions
PK150 is a potent antibiotic, which displays strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) at a sub-micromolar level. It elicits anti-biofilm activity and eliminates persisters. PK150 also shows oral bioavailability, and in vivo efficacy in mouse model.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable