SBR00043
PK150
Sorafenib analog
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关于此项目
经验公式（希尔记法）:
C15H8ClF5N2O3
化学文摘社编号:
分子量:
394.68
UNSPSC Code:
51112008
NACRES:
NA.76
MDL number:
SMILES string
FC1(Oc2c(ccc(c2)NC(=O)Nc3cc(c(cc3)Cl)C(F)(F)F)O1)F
InChI
1S/C15H8ClF5N2O3/c16-10-3-1-7(5-9(10)14(17,18)19)22-13(24)23-8-2-4-11-12(6-8)26-15(20,21)25-11/h1-6H,(H2,22,23,24)
InChI key
SHPYXCLUNMOJOB-UHFFFAOYSA-N
form
powder
antibiotic activity spectrum
Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
Quality Level
General description
PK150 is a recently discovered small antimicrobial compound. It is a potent analog of sorafenib, an anticancer drug. PK150 has structural similarity with triclocarban (TCC) and triclosan (TCS) with a N,N′-diaryl urea motif in common.
Biochem/physiol Actions
PK150 is a potent antibiotic, which displays strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) at a sub-micromolar level. It elicits anti-biofilm activity and eliminates persisters. PK150 also shows oral bioavailability, and in vivo efficacy in mouse model.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Philipp Le et al.
Nature chemistry, 12(2), 145-158 (2019-12-18)
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural
Robert Macsics et al.
Applied and environmental microbiology, 86(16) (2020-06-07)
Triclocarban (TCC), a formerly used disinfectant, kills bacteria via an unknown mechanism of action. A structural hallmark is its N,N'-diaryl urea motif, which is also present in other antibiotics, including the recently reported small molecule PK150. We show here that
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