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SBR00065

Rifampicin

Name: Rifampicin
Brand: SIGMA

Ready Made Solution, 50 mg/mL in DMSO

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About This Item

Empirical Formula (Hill Notation):

C₄₃H₅₈N₄O₁₂

CAS Number:

13292-46-1

Molecular Weight:

822.94

UNSPSC Code:

41116107

NACRES:

NA.76

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Properties

Quality Level

200

form

liquid, ready-to-use solution

specific activity

Antibacterial

concentration

50 mg/mL in DMSO

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, viruses

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

Description

General description

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

Application

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Other Notes

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number

0000411085

0000345737

0000328305

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Guidelines for the Management of Cholestatic Liver Diseases (2021)

Lu, Lungen

Journal of clinical and translational hepatology (2022)

Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles

Peyret, Hadrien, et al

Methods in Molecular Biology, 103-111 (2022)

Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities

Howell, Pauline, et al.

Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBR00065-1ML	04065268864999