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Merck
CN

SBR00065

Rifampicin

Ready Made Solution, 50 mg/mL in DMSO

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About This Item

Empirical Formula (Hill Notation):
C43H58N4O12
CAS Number:
13292-46-1
Molecular Weight:
822.94
UNSPSC Code:
41116107
NACRES:
NA.76

Key Documents

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Product Name

Rifampicin, Ready Made Solution, 50 mg/mL in DMSO

Quality Level

200

SMILES string

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

form

liquid
ready-to-use solution

specific activity

Antibacterial

concentration

50 mg/mL in DMSO

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

mode of action

protein synthesis | interferes

storage temp.

−20°C

Related Categories

Other Notes

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

Application

  • Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
  • Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
  • Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
  • Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

General description

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

hcodes

H362

Hazard Classifications

Lact.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000411085
0000411085
0000345737
0000328305
0000328305

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Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
Umeda, Tomohiro, et al
Biomedicines, 10.2, 297-297 (2022)
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles
Peyret, Hadrien, et al
Methods in Molecular Biology, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)

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