Skip to Content
Merck
CN

Key Documents

View All Documentation

SBR00068

Streptomycin

Ready Made Solution, 100 mg/mL in water

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

CAS Number:
3810-74-0
UNSPSC Code:
51281624
NACRES:
NA.76
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

form

liquid, ready-to-use solution

specific activity

(Antibacterial)

concentration

100 mg/mL in water

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

application(s)

advanced drug delivery

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.[S](=O)(=O)(O)O.N([C@@H]4[C@@H](O[C@H]([C@@H]([C@H]4O)O)CO)O[C@H]5[C@@H](O[C@H]([C@]5(O)C=O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H]([C@@H]6O)O)N=C(N)N)O)N=C(N)N)C.N([C@@H]1[C@@H](O[C@H]([C@@H]([C@H]1O)O)CO)O[C@H]2[C@@H](O[C@H]([

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

General description

Chemical structure: aminoglycoside

Application

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50 μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Preparation Note

  • Streptomycin ready made solution contains 100 mg/mL streptomycin sulfate in water.
  • Streptomycin: sulfate salt ratio is 1:1.5.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

涉药品监管产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000490053
0000490053
0000490052
0000490052
0000375906

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Daniela Lobenwein et al.
Journal of the American Heart Association, 4(10), e002440-e002440 (2015-10-29)
Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. Shock wave treatment was shown to induce angiogenesis and regeneration in ischemic tissue by modulation of early inflammatory response via Toll-like receptor (TLR)
Rabia T Khan et al.
PloS one, 9(2), e88009-e88009 (2014-02-08)
Experimental animal models of Salmonella infections have been widely used to identify genes important in the host immune response to infection. Using an F2 cross between the classical inbred strain C57BL/6J and the wild derived strain MOLF/Ei, we have previously
Jiayun Zhu et al.
Cell cycle (Georgetown, Tex.), 14(12), 1809-1822 (2015-06-18)
Fanconi Anemia (FA) is a cancer predisposition syndrome and the factors defective in FA are involved in DNA replication, DNA damage repair and tumor suppression. Here, we show that FANCD2 is critical for genome stability maintenance in response to high-linear
View All Related Papers

Global Trade Item Number

SKUGTIN
SBR00068-10ML04065268958797