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Merck
CN

SBR00075

Sigma-Aldrich

Avibactam Sodium Salt

≥97% (HPLC), powder

Synonym(s):

NXL-104

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About This Item

Empirical Formula (Hill Notation):
C7H11N3NaO6S
CAS Number:
1192491-61-4
Molecular Weight:
288.23
UNSPSC Code:
51101500

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Quality Level

100

Assay

≥97% (HPLC)

form

powder

storage condition

under inert gas (Nitrogen)

color

white

antibiotic activity spectrum

Gram-negative bacteria

Mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

SMILES string

C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)[O-])C(=O)N.[Na+]

InChI

InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1

InChI key

RTCIKUMODPANKX-JBUOLDKXSA-M

Related Categories

General description

Avibactam sodium is a β-lactamase inhibitor and β-Lactamases are responsible for resistance to penicillins, monobactams, carbapenems, and extended-spectrum cephalosporins. It is a synthetic molecule with activity against gram-negative bacteria.

Application

Avibactam and related compounds have been studied for their ability to inhibit a variety of beta-lactamases, which are enzymes that inactivate beta-lactam antibiotics such as penicillin. The development of new beta-lactamase inhibitors like Avibactam is important for combating antibiotic resistance.

Biochem/physiol Actions

Avibactam is a β-lactamase inhibitor which inhibits the activity of β-lactamases by binding to the active site of β-lactamases and blocks the access of the substrate to the enzyme. Avibactam is effective against bacteria resistant to ceftazidime like Escherichia coli.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000354398
0000354398

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