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SBR00076

Baricitinib

Name: Baricitinib
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

INCB 028050, LY 3009104

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₇N₇O₂S

CAS Number:

1187594-09-7

Molecular Weight:

371.42

UNSPSC Code:

51101500

NACRES:

NA.41

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

application(s)

advanced drug delivery

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

InChI

InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

InChI key

XUZMWHLSFXCVMG-UHFFFAOYSA-N

General description

Baricitinib is an antibiotic which belongs to a class of compound called known as Janus kinase (JAK) inhibitors. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways.

Application

Baricitinib has been studied for its ability to inhibit Janus kinases (JAKs), which play a crucial role in the signaling pathways involved in inflammation and immune responses. JAK inhibitors like Baricitinib have potential applications in the treatment of a variety of autoimmune and inflammatory diseases.

Biochem/physiol Actions

Baricitinib inhibits the activity of JAK enzymes, which are involved in cytokine signaling, leading to the suppression of inflammation and immune activation. Specifically, baricitinib inhibits JAK1 and JAK2 enzymes, which are associated with the signaling of different cytokines such as interleukin-6 (IL-6), interferon gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF). By inhibiting JAK enzymes, baricitinib reduces the activity of these cytokines and suppresses inflammation and immune activation.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H335,H360FD,H372

pcodes

P202 - P260 - P264 - P271 - P280 - P308 + P313

Hazard Classifications

Repr. 1B - STOT RE 1 - STOT SE 3

target_organs

Blood,Bone marrow,lymphatic system, Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000363750

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Global Trade Item Number

SKU	GTIN
SBR00076-10MG	04065271124523

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