SBR00076
Baricitinib
≥98% (HPLC), powder
Synonym(s):
INCB 028050, LY 3009104
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About This Item
Empirical Formula (Hill Notation):
C16H17N7O2S
CAS Number:
Molecular Weight:
371.42
UNSPSC Code:
51101500
NACRES:
NA.41
Quality Segment
assay
≥98% (HPLC)
form
powder
color
off-white
application(s)
advanced drug delivery
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChI
InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChI key
XUZMWHLSFXCVMG-UHFFFAOYSA-N
General description
Baricitinib is an antibiotic which belongs to a class of compound called known as Janus kinase (JAK) inhibitors. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways.
Application
Baricitinib has been studied for its ability to inhibit Janus kinases (JAKs), which play a crucial role in the signaling pathways involved in inflammation and immune responses. JAK inhibitors like Baricitinib have potential applications in the treatment of a variety of autoimmune and inflammatory diseases.
Biochem/physiol Actions
Baricitinib inhibits the activity of JAK enzymes, which are involved in cytokine signaling, leading to the suppression of inflammation and immune activation. Specifically, baricitinib inhibits JAK1 and JAK2 enzymes, which are associated with the signaling of different cytokines such as interleukin-6 (IL-6), interferon gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF). By inhibiting JAK enzymes, baricitinib reduces the activity of these cytokines and suppresses inflammation and immune activation.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Repr. 1B - STOT RE 1 - STOT SE 3
Target Organs
Blood,Bone marrow,lymphatic system, Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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