SBR00077
Dapivirine
≥95% (H-NMR), powder
Synonym(s):
TMC 120
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About This Item
Empirical Formula (Hill Notation):
C20H19N5
CAS Number:
Molecular Weight:
329.40
UNSPSC Code:
51101500
NACRES:
NA.41
InChI
1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)
InChI key
ILAYIAGXTHKHNT-UHFFFAOYSA-N
SMILES string
CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
assay
≥95% (H-NMR)
form
powder
color
white to off-white
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | inhibits
storage temp.
2-8°C
Quality Level
General description
Dapivirine is an antibiotic from a class of nn-nucleoside reverse transcriptase inhibitor compounds. Dapivirine, a substituted diarylpyrimidine derivative, irreversibly binds to and inhibits HIV reverse transcriptase which prevents the conversion of viral RNA to proviral DNA.
Biochem/physiol Actions
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor and has activity against wild-type virus strains and strains harboring different NNRTI resistance-inducing mutations.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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