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Merck
CN

SBR00080

Dolutegravir

Synonym(s):

GSK 1349572

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About This Item

Empirical Formula (Hill Notation):
C20H19F2N3O5
CAS Number:
1051375-16-6
Molecular Weight:
419.38
UNSPSC Code:
51101500
NACRES:
NA.41

Key Documents

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InChI

1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1

InChI key

RHWKPHLQXYSBKR-BMIGLBTASA-N

SMILES string

C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

assay

≥98% (HPLC)

form

powder

color

white to off-white

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

Quality Level

100

General description

Dolutegravir is an antibioitic which belongs to the class of compounds known as integrase strand transfer inhibitors (INSTIs).

Biochem/physiol Actions

Dolutegravir inhibits HIV-1 viral replication, high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants. Dolutegravir inhibitis the action of the HIV integrase enzyme, which is necessary for the integration of viral DNA into the host genome, thereby preventing viral replication and reducing HIV viral load.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000354401
0000354401

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