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Merck
CN

SBR00080

Sigma-Aldrich

Dolutegravir

Synonym(s):

GSK 1349572

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About This Item

Empirical Formula (Hill Notation):
C20H19F2N3O5
CAS Number:
1051375-16-6
Molecular Weight:
419.38
UNSPSC Code:
51101500

Key Documents

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Assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to off-white

antibiotic activity spectrum

viruses

Mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O

InChI

1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1

InChI key

RHWKPHLQXYSBKR-BMIGLBTASA-N

General description

Dolutegravir is an antibioitic which belongs to the class of compounds known as integrase strand transfer inhibitors (INSTIs).

Biochem/physiol Actions

Dolutegravir inhibits HIV-1 viral replication, high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants. Dolutegravir inhibitis the action of the HIV integrase enzyme, which is necessary for the integration of viral DNA into the host genome, thereby preventing viral replication and reducing HIV viral load.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000354401
0000354401

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