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Merck
CN

SBR00088

Rilpivirine

≥95% (HPLC), powder

Synonym(s):

4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278

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About This Item

Empirical Formula (Hill Notation):
C22H18N6
CAS Number:
500287-72-9
Molecular Weight:
366.42
UNSPSC Code:
51101500
MDL number:
MFCD11046372
NACRES:
NA.21

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InChI key

YIBOMRUWOWDFLG-ONEGZZNKSA-N

InChI

1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+

SMILES string

CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N

assay

≥95% (HPLC)

form

powder

color

white to yellow, or beige

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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General description

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Biochem/physiol Actions

Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral
Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.
Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000381680
0000381680

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