SBR00088
Rilpivirine
≥95% (HPLC), powder
Synonym(s):
4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
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About This Item
Empirical Formula (Hill Notation):
C22H18N6
CAS Number:
Molecular Weight:
366.42
UNSPSC Code:
51101500
MDL number:
NACRES:
NA.21
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to yellow, or beige
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
shipped in
ambient
storage temp.
−20°C
SMILES string
CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
InChI
1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChI key
YIBOMRUWOWDFLG-ONEGZZNKSA-N
General description
Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Biochem/physiol Actions
Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral
Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.
Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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