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Merck
CN

SBR00089

Sotorasib

≥98% (HPLC), solid

Synonym(s):

AMG-510

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About This Item

Empirical Formula (Hill Notation):
C30H30F2N6O3
CAS Number:
2252403-56-6
Molecular Weight:
560.59
UNSPSC Code:
51101500
NACRES:
NA.41

Key Documents

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InChI

InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

InChI key

NXQKSXLFSAEQCZ-SFHVURJKSA-N

SMILES string

C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C

assay

≥98% (HPLC)

form

solid

color

off-white to yellow

mode of action

protein synthesis | inhibits

Quality Level

100

General description

Sotorasib (INN) is a small molecule which belongs to the class of compounds known as KRAS G12C inhibitors. Sotorasib is a chiral compound which is a KRAS G12C covalent inhibitor.

Biochem/physiol Actions

Sotorasib inhibits the KRAS G12C protein, which is involved in the regulation of cell growth and division. The KRAS G12C protein is a mutated form of the KRAS protein, which is found in certain types of cancer cells, particularly non-small cell lung cancer (NSCLC). The G12C mutation causes abnormal activation of the KRAS G12C protein, leading to the uncontrolled growth and spread of cancer cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000520201
0000520201
0000401612
0000401612

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