SBR00097
Sancycline
≥95% (H-NMR), powder
Synonym(s):
6-Demethyl-6-deoxytetracycline, Bonomycin, Norcycline
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About This Item
Empirical Formula (Hill Notation):
C21H22N2O7
CAS Number:
Molecular Weight:
414.41
UNSPSC Code:
51101500
NACRES:
NA.21
Quality Level
assay
≥95% (H-NMR)
form
powder
color
yellow to brown
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma
application(s)
advanced drug delivery
mode of action
protein synthesis | inhibits
shipped in
ambient
storage temp.
−20°C
SMILES string
CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C(=CC=C4)O)C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O
InChI
1S/C21H22N2O7/c1-23(2)15-10-7-9-6-8-4-3-5-11(24)12(8)16(25)13(9)18(27)21(10,30)19(28)14(17(15)26)20(22)29/h3-5,9-10,15,24-25,28,30H,6-7H2,1-2H3,(H2,22,29)/t9-,10-,15-,21-/m0/s1
InChI key
MTCQOMXDZUULRV-ADOAZJKMSA-N
General description
Sancycline is an antibioitic which belongs to the class of compounds known as tetracycline antibiotics. It is a semisynthetic derivative of naturally occurring tetracycline and is used in the treatment of bacterial infections caused by susceptible organisms. Sancycline is active against a wide range of Gram-positive and Gram-negative bacteria, as well as atypical bacteria such as Mycoplasma and Chlamydia species.
Biochem/physiol Actions
Sancycline inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and bacterial death.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SBR00097-5MG | 04065271975347 |
| SBR00097-100MG | 04065272827737 |