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About This Item
Empirical Formula (Hill Notation):
C11H13BrN2O5
CAS Number:
Molecular Weight:
333.14
UNSPSC Code:
51101500
MDL number:
NACRES:
NA.21
InChI key
ODZBBRURCPAEIQ-PIXDULNESA-N
InChI
1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1
SMILES string
O=C(C(/C=C/Br)=CN1[C@H]2C[C@H](O)[C@@H](CO)O2)NC1=O
assay
≥95%
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
shipped in
ambient
storage temp.
2-8°C
Quality Level
Related Categories
General description
Brivudine is a synthetic nucleoside analogue antibiotic. It has structural similarities to the natural nucleoside deoxyuridine.
Application
Brivudine has bee used: - in the research of pancreatic cancer
Biochem/physiol Actions
Mode of Action: Brivudine blocks the action of DNA polymerases, inhibiting viral replication.
Antimicrobial Spectrum: Active against Varicella zoster virus and Herpes simplex virus
Antimicrobial Spectrum: Active against Varicella zoster virus and Herpes simplex virus
Features and Benefits
High quality antibiotic suitable for mulitple research applications Commonly used in Cell Biology and Biochemical applications
Regulatory Information
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Jörg-Christian Heinrich et al.
Journal of cancer research and clinical oncology, 137(9), 1349-1361 (2011-08-13)
Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer.
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