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Merck
CN

SBR00119

Sigma-Aldrich

Sarecycline Hydrochloride

Synonym(s):

P-005672 HCl, P005672 HCl

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About This Item

Empirical Formula (Hill Notation):
C24H30ClN3O8
CAS Number:
1035979-44-2
Molecular Weight:
523.96
UNSPSC Code:
51101500

Key Documents

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storage condition

under inert gas

Quality Level

100

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

protein synthesis | inhibits

shipped in

ambient

storage temp.

2-8°C

SMILES string

CN(C)[C@H]1[C@H]2C[C@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)CN(C)OC.Cl

InChI

1S/C24H29N3O8.ClH/c1-26(2)18-13-8-11-7-12-10(9-27(3)35-4)5-6-14(28)16(12)19(29)15(11)21(31)24(13,34)22(32)17(20(18)30)23(25)33;/h5-6,11,13,18,28-29,32,34H,7-9H2,1-4H3,(H2,25,33);1H/t11-,13-,18-,24-;/m0./s1

InChI key

JGPBDCKZLBSHOI-FIPJBXKNSA-N

General description

Sarecycline Hydrochloride is an antibioitc which belongs to the class of couponds know as tetracycline antibiotics. It is a modified derivative of naturally occurring tetracyclines. Sarecycline Hydrochloride is active against a wide range of Gram-positive and Gram-negative bacteria,

Biochem/physiol Actions

Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria that are associated with acne.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000415441
0000415441

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