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Merck
CN

SCP0001

Autocamptide-2 Related Inhibitor Peptide

Synonym(s):

AIP

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About This Item

Empirical Formula (Hill Notation):
C78H142N22O20
Molecular Weight:
1708.10
NACRES:
NA.32
UNSPSC Code:
12352202
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Application

Autocamptide-2 Related Inhibitor Peptide (AIP) is highly specific inhibitor of calmodulin-dependent protein kinase II (CaMKII) that may be used to study the role of CaMKII in processes such as heart failure.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

This item has



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Vassilios J Bezzerides et al.
Circulation, 140(5), 405-419 (2019-06-04)
Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately treated by current standard of care. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an adrenergically activated kinase that contributes to arrhythmogenesis in heart disease models, is
CaMKII inhibition in heart failure makes jump to human.
Donald M Bers
Circulation research, 107(9), 1044-1046 (2010-10-30)
A Ishida et al.
FEBS letters, 427(1), 115-118 (1998-06-05)
The importance of the individual amino acid residues of AIP (KKALRRQEAVDAL), a highly specific inhibitor of calmodulin-dependent protein kinase II (CaMKII), was studied. Replacement of Arg6, Gln7, or Ala9 by other amino acid residues produced a marked increase in the



Global Trade Item Number

SKUGTIN
SCP0001-5MG04061833024485