SCP0002
Acetyl-Amyloid β 25-35
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About This Item
Empirical Formula (Hill Notation):
C47H83N13O15S1
Molecular Weight:
1102.31
NACRES:
NA.32
UNSPSC Code:
12352202
General description
Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The amyloid β precursor protein is cleaved to amyloid peptides 36-43 amino acids in length. Aβ (25-35) represents the region that aggregates during plaque formation and is a functional domain implicated in both neurotrophic and neurotoxic effects. The gene encoding amyloid-β is localized on human chromosome 21. Acetylation may improve stability in in vitro and in vivo assays.
Application
Acetyl-Amyloid β 25-35 has been used to prepare rat models with Alzheimer′s disease.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Conformational Dynamics of Specific A? Oligomers Govern Their Ability To Replicate and Induce Neuronal Apoptosis.
Dean DN
Biochemistry, 55(15), 2238-2250 (2016)
Effect of yizhitongxuan decoction on learning and memory ability, Gaq/11 expression and Na(+)-K(+)-ATP enzyme activity in rat models of Alzheimer's disease.
Teng J
Journal of Traditional Chinese Medicine = Chung i Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, 34(4), 470-476 (2014)
Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering.
Zhang-Haagen B
PLoS ONE, 11(2), e0150267-e0150267 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SCP0002-5MG | 04061833024492 |
| SCP0002-1MG | 04061837017452 |