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SCP0002

Acetyl-Amyloid β 25-35

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About This Item

Empirical Formula (Hill Notation):
C47H83N13O15S1
Molecular Weight:
1102.31
NACRES:
NA.32
UNSPSC Code:
12352202
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

UniProt accession no.

P05067

storage temp.

−20°C

Gene Information

human ... APP(351)

General description

Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The amyloid β precursor protein is cleaved to amyloid peptides 36-43 amino acids in length. Aβ (25-35) represents the region that aggregates during plaque formation and is a functional domain implicated in both neurotrophic and neurotoxic effects. The gene encoding amyloid-β is localized on human chromosome 21. Acetylation may improve stability in in vitro and in vivo assays.

Application

Acetyl-Amyloid β 25-35 has been used to prepare rat models with Alzheimer′s disease.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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