SCP0004
γ Secretase Inhibitor
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C26H41N3O5
Molecular Weight:
475.62
NACRES:
NA.32
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
General description
Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors.
Application
γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Cleonice Michelon et al.
Molecular neurobiology, 57(2), 1159-1169 (2019-11-09)
Inflammatory cytokines are related to impaired learning and memory processes in the central nervous system, contributing to the cognitive dysfunction present in sepsis survivors. In sepsis, brain of survivors presented increased deposition of amyloid-beta (Aβ) peptide and this was associated
MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells.
Xiao G, et al.
Oncotarget, 8(61), 103261-103261 (2017)
Tao Na et al.
BMC cancer, 20(1), 1064-1064 (2020-11-06)
Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechanisms responsible for regulating the immunomodulation of hMSCs still remain largely unknown.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SCP0004-5MG | 04061833024515 |