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Merck
CN

SCP0010

Adrenomedullin 11-50 rat

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About This Item

Empirical Formula (Hill Notation):
C194H304N58O59S4
Molecular Weight:
4521.10
NACRES:
NA.32
UNSPSC Code:
12352200
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Application

Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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J Cornish et al.
Current pharmaceutical design, 8(23), 2009-2021 (2002-08-13)
Bone growth is regulated by circulating hormones and locally generated factors. Understanding their mechanisms of action enables us to obtain a better appreciation of the cellular and molecular basis of bone remodelling, and could therefore be valuable in approaches to
Susan D Brain et al.
Physiological reviews, 84(3), 903-934 (2004-07-23)
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37-amino acid neuropeptide, primarily released from sensory nerves, whilst AM is produced by stimulated vascular cells, and amylin
B Lin et al.
European journal of pharmacology, 260(1), 1-4 (1994-07-21)
The present study was undertaken to investigate the effects of human adrenomedullin, a newly discovered peptide present in normal human plasma, as well as a fragment of adrenomedullin, on systemic hemodynamics in the anesthetized rat. Intravenous (i.v.) bolus injections of



Global Trade Item Number

SKUGTIN
SCP0010-1MG04061823600613
SCP0010-500UG04061833024553