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Merck
CN

SCP0018

[Asn1,Val5,Asn9]-Angiotensin I salmon

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About This Item

Empirical Formula (Hill Notation):
C59H87N17O14
Molecular Weight:
1258.43
NACRES:
NA.32
UNSPSC Code:
12352209
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Application

Angiotensins are peptide hormone components of the renin-angiotensin system involved in the regulation of blood vessel constriction and aldosterone release. Angiotensin I, a decapeptide derived from angiotensinogen, is a converted to Angiotensin II by the removal of the two C-terminal amino acids. Various analogues of Angiotensin I may be used as substrates to identify, differentiate and characterize angiotensin-converting enzyme(s) (ACE).

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Yoshio Takei et al.
General and comparative endocrinology, 135(3), 286-292 (2004-01-16)
In order to delineate further the molecular evolution of the renin-angiotensin system in vertebrates, angiotensin I (ANG I) has been isolated after incubation of plasma and kidney extracts of emu (Dromiceus novaehollandiae), axolotl (Ambystoma mexicanum), and sea lamprey (Petromyzon marinus).
N J Bernier et al.
The American journal of physiology, 273(1 Pt 2), R49-R57 (1997-07-01)
Immunohistochemical and pharmacological techniques were utilized to investigate the relationships between angiotensins and catecholamine release from the chromaffin tissue of rainbow trout (Oncorhynchus mykiss). Double labeling with [Asp1, Ile5]angiotensin II-fluorescein isothiocyanate (ANG II-FITC) and anti-dopamine beta-hydroxylase revealed specific ANG II
M C Khosla et al.
Hypertension (Dallas, Tex. : 1979), 5(6 Pt 3), V22-V28 (1983-11-01)
To understand how vertebrates utilize angiotensins during evolutionary development, we undertook studies to synthesize and/or characterize angiotensin-like peptides from nonmammalian species. The present paper describes the synthesis of [Asp1,Val5,Asn9] angiotensin I (bull frog, Rana catesbeiana) (I), [Asn1,Val5,His9] angiotensin I (Japanese

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