SCP0029
[Gly22]-Amyloid β 1-40 Arctic human
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C191H291N53O56S1
Molecular Weight:
4257.74
NACRES:
NA.77
UNSPSC Code:
12352209
General description
β-Amyloid peptides are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease. Aβ (1-40) whether soluble or insoluble differentiates AD vs high pathology controls. The Arctic mutation E22G causes early onset of Alzheimer′s compared to wild type and promotes protofibril formation and neurotoxicity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Anna Itkin et al.
PloS one, 6(3), e18250-e18250 (2011-04-06)
Amyloid β-peptide (Aβ) is directly linked to Alzheimer's disease (AD). In its monomeric form, Aβ aggregates to produce fibrils and a range of oligomers, the latter being the most neurotoxic. Dysregulation of Ca(2+) homeostasis in aging brains and in neurodegenerative
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SCP0029-1MG | 04061826693131 |
| SCP0029-500UG | 04061833024652 |