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SCP0074

Caspase 13 Substrate

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):
C32H41N5O13
Molecular Weight:
703.69
UNSPSC Code:
12352202
NACRES:
NA.32
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Product Name

Caspase 13 Substrate,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥65%

storage condition

protect from light

storage temp.

−20°C

Application

Caspase 13 (ERICE), an orthologue of human caspase 4, is a cysteine protease which may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEED (Leu-Glu-Glu-Asp) sequence. These substrates include: Ac-LEED-pNa (acetyl-Leu-Glu-Glu-Asp-p-nitroanalide), chromogenic and Ac-LEED-AMC (Acetyl-Leu-Glu-Glu-Asp- amino-4-methylcoumarin), fluorogenic.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
LD0558

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U Koenig et al.
Biochemical and biophysical research communications, 285(5), 1150-1154 (2001-08-02)
Caspase-13 was reported to be a member of the human caspase family of proteases (Humke, E., et al., J. Biol. Chem. 273, 15702-15707, 1998). By contrast, a recent study (Lin, X., et al., J. Biol. Chem. 275, 39920-39926, 2000) could
S Taylor et al.
DNA sequence : the journal of DNA sequencing and mapping, 10(6), 387-394 (2000-05-29)
Caspases are cysteine proteases which have important roles in the activation of cytokines and in apoptosis. The ICE subfamily of caspases comprise peptides closely related to caspase-1, or interleukin-1beta (IL-1beta) converting enzyme (ICE), which promotes maturation of interleukin IL-1beta and
E W Humke et al.
The Journal of biological chemistry, 273(25), 15702-15707 (1998-06-23)
Programmed cell death, or apoptosis, is a process of fundamental importance to cellular homeostasis in metazoan organisms (Ellis, R. E., Yuan, J., and Horvitz, H. R. (1991) Annu. Rev. Cell Biol. 7, 663-698). The caspase family of mammalian proteases, related

Global Trade Item Number

SKUGTIN
SCP0074-5MG04061833266182