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SCP0082

Caspase 3 Apopain Substrate

Name: Caspase 3 Apopain Substrate
Brand: SIGMA

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₃₈N₅O₁₄

Molecular Weight:

764.71

UNSPSC Code:

12352202

NACRES:

NA.32

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Properties

Product Name

Caspase 3 Apopain Substrate,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Description

Application

Caspase 3, a cysteine protease activator of caspase 6 and caspase 7, metabolizes amyloid-β 4A precursor protein. Caspase 3 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the DxxD (asp-x-x-asp) sequences DMQD and DEVD such as Ac-DMQD-pNa (Acetyl-Asp-Met-Gln-Asp-p- nitroanalide), chromogenic; Ac-DMQD-AMC (Acetyl-Asp-Met-Gln-Asp-amino-4-methylcoumarin), fluorogenic; Z-DEVD-AFC (Z-Asp-Glu-Val-Asp-AFC), flourogenic and Ac-DEVD-4M2Na.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

LM0818

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Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.

R Datta et al.

Blood, 88(6), 1936-1943 (1996-09-15)

The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in

Activation of p38 mitogen-activated protein kinase and caspases in UVB-induced apoptosis of human keratinocyte HaCaT cells.

H Shimizu et al.

The Journal of investigative dermatology, 112(5), 769-774 (1999-05-08)

Exposure of human keratinocyte HaCaT cells to ultraviolet B-irradiation induced apoptotic morphologic changes. In this study, we found that the ultraviolet B irradiation (0.25 J per cm2) induced phosphorylation of p38 mitogen-activated protein kinase and c-jun N-terminal protein kinase, and

Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury.

Osman Akdemir et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 15(6), 672-678 (2008-04-02)

We investigated the therapeutic efficacy of Ac-DMQD-CHO, a caspase-3 inhibitor, and functional recovery in spinal cord injury in a rat model. Thirty rats were randomized into three groups of 10 each. In groups 2 and 3, spinal cord trauma was

Global Trade Item Number

SKU	GTIN
SCP0082-5MG	04061833024782