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SCP0131

Sigma-Aldrich

ECE-1 Substrate

≥95% (HPLC)

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Empirical Formula (Hill Notation):
C66H81N15O19
Molecular Weight:
1388.44
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥50%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-DNP-Lys

Application

MCA-RPPGFSAF-DNP-K (Mca-RPPGFSAFK(Dnp)) is a fluorogenic substrate used to assay Angiotensin converting enzyme (ACE-1), insulin-degrading enzyme and Endothelin converting enzyme 1 (ECE-1) activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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James Scott Miners et al.
Journal of neuroscience methods, 169(1), 177-181 (2008-01-29)
Internally quenched fluorogenic substrates are commonly used for measuring enzyme activity in biological samples and allow high sensitivity and continuous real-time measurement that is well suited for high throughput analysis. We describe the development and optimisation of an immunocapture-based assay
Jeff C Joyner et al.
Journal of the American Chemical Society, 134(7), 3396-3410 (2011-12-28)
A series of compounds that target reactive transition-metal chelates to somatic angiotensin converting enzyme (sACE-1) have been synthesized. Half-maximal inhibitory concentrations (IC(50)) and rate constants for both inactivation and cleavage of full-length sACE-1 have been determined and evaluated in terms
Juan-Carlos Pelayo et al.
The Journal of physiology, 589(Pt 21), 5213-5230 (2011-09-01)
Neuropeptide signalling at the plasma membrane is terminated by neuropeptide degradation by cell-surface peptidases, and by β-arrestin-dependent receptor desensitization and endocytosis. However, receptors continue to signal from endosomes by β-arrestin-dependent processes, and endosomal sorting mediates recycling and resensitization of plasma
Burcu Hasdemir et al.
Molecular endocrinology (Baltimore, Md.), 26(4), 681-695 (2012-02-11)
CRF receptor 1 (CRF(1)), a key neuroendocrine mediator of the stress response, has two known agonists corticotropin-releasing factor (CRF) and urocortin 1 (Ucn1). Here we report that endothelin-converting enzyme-1 (ECE-1) differentially degrades CRF and Ucn1; ECE-1 cleaves Ucn1, but not

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