SCP0137
Endothelin Receptor Antagonist W 7338A
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About This Item
Empirical Formula (Hill Notation):
C30H42N6O7
Molecular Weight:
598.69
NACRES:
NA.32
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
Application
Endothelin Receptor Antagonist W-7338A isolated from Streptomyces sp. No. 7338 is used as an endothelin receptor antagonist.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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S Miyata et al.
The Journal of antibiotics, 45(1), 74-82 (1992-01-01)
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC.
Endothelin receptor antagonists: an overview of their synthesis and structure-activity relationship.
Javed Iqbal et al.
Mini reviews in medicinal chemistry, 5(4), 381-408 (2005-04-28)
Endothelins (ETs) are potent vasoconstrictor peptides and are associated with several disease states like pulmonary hypertension, systemic hypertension and heart failure. Endothelin-1 (ET-1) is the first member of the family and it has the receptor subtypes known as ETA and
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B.
S Miyata et al.
The Journal of antibiotics, 45(5), 788-791 (1992-05-01)
S Miyata et al.
The Journal of antibiotics, 45(1), 83-87 (1992-01-01)
WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular
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