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SCP0151

[Leu¹⁵,Gly¹⁸]-Gastrin^2-17

Name: [Leu15,Gly18]-Gastrin2-17
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₉₅H₁₂₃N₁₉O₃₁

Molecular Weight:

2027.10

NACRES:

NA.32

UNSPSC Code:

12352209

Form:

lyophilized

Assay:

≥95% (HPLC)

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Properties

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥70%

storage condition

protect from light

storage temp.

−20°C

Description

Application

Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells. Gastrin is found in three major forms: gastrin-34 (big gastrin); gastrin-17 (little gastrin) and gastrin-13 minigastrin.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

CC0471

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Gastrins, iron homeostasis and colorectal cancer.

Suzana Kovac et al.

Biochimica et biophysica acta, 1813(5), 889-895 (2011-02-16)

The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50 years

Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides.

J F Rehfeld

Acta physiologica (Oxford, England), 201(4), 405-411 (2011-03-12)

Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function.

Ana-Maria Cujba et al.

Cell reports, 38(9), 110425-110425 (2022-03-03)

The HNF1αp291fsinsC truncation is the most common mutation associated with maturity-onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the mechanism by which HNF1αp291fsinsC causes MODY3 is not fully understood. Here we use MODY3 patient and

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Global Trade Item Number

SKU	GTIN
SCP0151-500UG	04061833025116
SCP0151-1MG	04061823600712