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SCP0158

Granzyme B Substrate

Name: Granzyme B Substrate
Brand: SIGMA

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):

C₃₂H₄₁N₅O₁₁

Molecular Weight:

671.69

UNSPSC Code:

12352204

NACRES:

NA.32

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Properties

Product Name

Granzyme B Substrate,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

Description

Application

Granzyme B Substrate (Ac-IEPD-AMC) is a fluorogenic substrate for the detection and assay of caspase 8 and granzyme B which is involved in the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Biochem/physiol Actions

Granzymes belongs to serine proteinase family enzymes and it localizes along with perforin in granules. It is predominant in cytotoxic T cells. Granzyme B induces caspases dependent and independent cell death. It possesses specific cleavage action at aspartate residue in the substrate.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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