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SCP0169

HIV-1 Tat Peptide

Name: HIV-1 Tat Peptide
Brand: SIGMA

≥95% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):

C₆₅H₁₂₄N₃₄O₁₃

Molecular Weight:

1589.90

UNSPSC Code:

12352202

NACRES:

NA.32

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Product Name

HIV-TAT (48-57),

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥55%

storage condition

protect from light

storage temp.

−20°C

General description

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat), a regulatory protein is coded by the Tat gene of HIV-1. Tat is made up of two exons, highly conserved regions, and subtype-specific regions.

Biochem/physiol Actions

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat) participates in the pathogenesis of HIV-related complications. Tat protein is also involved in HIV-related cardiac dysfunction. HIV-TAT (48-57) is used to facilitate the internalization of synthetic peptides.

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

CI0935R

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Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK).

S-M Lee et al.

Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)

The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a

The role of HIV Tat protein in HIV-related cardiovascular diseases.

Yanan Jiang et al.

Journal of translational medicine, 16(1), 121-121 (2018-05-10)

The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which

Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K.

S-M Lee et al.

Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)

The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In

Global Trade Item Number

SKU	GTIN
SCP0169-1MG	04061826693681

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