SCP0224
Prostate Specific Antigen Substrate
≥95% (HPLC), lyophilized
Synonym(s):
KLK3, Kallikrein-related peptidase-3, PSA
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About This Item
Empirical Formula (Hill Notation):
C44H64N12O13
Molecular Weight:
969.05
UNSPSC Code:
12352204
NACRES:
NA.32
Product Name
Prostate Specific Antigen Substrate,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
General description
Prostate specific antigen (PSA) is a kallikrein-related serine peptidase that belongs to the chymotrypsin subfamily serine protease. It was originally found in human semen. PSA is also detected in serum correlated to benign and metastatic disease.
Application
Prostate Specific Antigen Substrate has been used to assay recombinant severe acute respiratory syndrome coronavirus-2 viral 3-chymotrypsin-like cysteine protease (SARS-CoV-2 3CLpro).
Biochem/physiol Actions
Prostate specific antigen (PSA). It exhibits chymotrypsin-like activity. PSA is the most abundant protease found in the prostate and secreted into the seminal fluid. It is a useful biomarker for prostate cancer. PSA digests the gel-forming proteins semenogelins I and II in semen. It shows antiangiogenic activity in vitro and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Drake M Mellott et al.
ACS chemical biology, 16(4), 642-650 (2021-04-01)
Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SARS-CoV-2 viral infectivity in several
G S Coombs et al.
Chemistry & biology, 5(9), 475-488 (1998-09-30)
The serine protease prostate-specific antigen (PSA) is a useful clinical marker for prostatic malignancy. PSA is a member of the kallikrein subgroup of the (chymo)trypsin serine protease family, but differs from the prototypical member of this subgroup, tissue kallikrein, in
Anneliese S Ashhurst et al.
Journal of medicinal chemistry, 65(4), 2956-2970 (2021-11-04)
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SCP0224-1MG | 04061826693933 |