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Sigma-Aldrich

Chebulinic acid

≥85% (LC/MS-ELSD)

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Synonym(s):
Eutannin
Empirical Formula (Hill Notation):
C41H32O27
CAS Number:
18942-26-2
Molecular Weight:
956.68
NACRES:
NA.25

Assay

≥85% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

InChI

1S/C41H32O27/c42-15-1-10(2-16(43)26(15)51)35(56)62-9-22-31-33(66-36(57)11-3-17(44)27(52)18(45)4-11)34(41(63-22)68-37(58)12-5-19(46)28(53)20(47)6-12)67-38(59)13-7-21(48)29(54)32-25(13)24(30(55)40(61)65-32)14(8-23(49)50)39(60)64-31/h1-7,14,22,24,30-31,33-34,41-48,51-55H,8-9H2,(H,49,50)/t14-,22+,24-,30-,31+,33-,34+,41-/m0/s1

InChI key

YGVHOSGNOYKRIH-FJPMMHPYSA-N

Related Categories

General description

Natural product derived from plant source.

Biochem/physiol Actions

Chebulinic acid is polyphenol that has shown antihypertensive, and anti-oxidant properties. Its antihypertensive effects may be due to decreased cardiac output from reduced left ventricular contraction.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Y Y Guan et al.
Clinical and experimental pharmacology & physiology, 23(8), 747-750 (1996-08-01)
1. The effects of chebulinic acid, which has been shown to elicit blood pressure lowering effect in rats, on aortic vascular contraction as well as cardiac contraction were studied in rats. 2. Chebulinic acid had no effect on KCl-induced aortic
Hyun-Sun Lee et al.
Journal of ethnopharmacology, 131(3), 567-574 (2010-07-28)
The aqueous extract of Terminalia chebular fruits was reported to have anti-hyperglycemia and anti-diabetic complication effects. The present study therefore investigated the protective mechanism of chebulic acid, a phenolcarboxylic acid compound isolated from the ripe fruits of Terminalia chebula against
Zong-Chun Yi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(4), 667-673 (2009-03-31)
The effects of two polyphenols, chebulinic acid and tellimagrandin I, on DNA strand breaks mediated by H(2)O(2)/Cu(II), hydroquinone (HQ)/Cu(II) and H(2)O(2)/Fe(II) in pBR322 plasmid DNA and genomic DNA of cultured MRC-5 human embryo lung fibroblasts were examined. The results demonstrated
Zong-chun Yi et al.
Acta pharmacologica Sinica, 25(2), 231-238 (2004-02-11)
To study effects of chebulinic acid on erythroid and megakaryocytic differentiation in K562 cells. The benzidine staining method was used to evaluate hemoglobin synthesis; the expression of erythroid specific glycophorin A (GPA) protein and megakaryocytic surface marker CD61 was determined
Hari Prasad Devkota et al.
Journal of natural medicines, 64(2), 191-193 (2009-12-29)
A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester (2) was isolated from the leaves of Sapium insigne (Royle) Benth. ex Hook. fil. (Euphorbiaceae) along with three known compounds gallic acid (1), brevifolin carboxylic acid (3) and fraxin (4). Structures of those
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