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SMB00372

Cycloastragenol

≥98% (HPLC)

Synonym(s):

(3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol, Astramembrangenin, Cyclogalegigenin, Cyclosieversigenin

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About This Item

Empirical Formula (Hill Notation):
C30H50O5
CAS Number:
78574-94-4
Molecular Weight:
490.72
NACRES:
NA.25
PubChem Substance ID:
329824975
UNSPSC Code:
12352205
MDL number:
MFCD24849201
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Quality Level

200

assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

C[C@]1(O[C@H](C(O)(C)C)CC1)[C@@]2([H])[C@@H](O)C[C@@]3(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C6)[C@]46CC[C@@]32C

InChI

1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1

InChI key

WENNXORDXYGDTP-UOUCMYEWSA-N

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General description

Cycloastragenol is a sapogenin and an aglycone found in or derived from Astragalus membranaceus. It is a natural triterpenoid.

Biochem/physiol Actions

Cycloastragenol is used as a nutraceutical (e.g. TAT2) and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. Cycloastragenol possesses antiviral, antimicrobial, anti-inflammatory, anti-hepatotoxic, anti-leukemia, antitumor and antinociceptive activity. It also acts as an immunomodulator.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000499276
0000499276
0000489861
0000489861
0000477163

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In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator
Zhu J, et al.
Drug Metabolism and Pharmacokinetics, 25(5), 477-486 (2010)

Global Trade Item Number

SKUGTIN
SMB00372-20MG04061833051955
SMB00372-100MG04061833051948

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