SMB00607
Amoxicillin trihydrate: potassium clavulanate (4:1)
Synonym(s):
Amoxicillin Trihydrate: Potassium Clavulanate
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About This Item
NACRES:
NA.85
UNSPSC Code:
51285005
form
powder
Quality Level
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)
color
white to yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
General description
Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.
Application
Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.
Biochem/physiol Actions
Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.
Packaging
1G
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.
Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SMB00607-1G | 04061837076527 |