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Merck
CN

SMB00607

Amoxicillin trihydrate: potassium clavulanate (4:1)

Synonym(s):

Amoxicillin Trihydrate: Potassium Clavulanate

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About This Item

NACRES:
NA.85
UNSPSC Code:
51285005
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form

powder

Quality Segment

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

color

white to yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

General description

Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.

Application

Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.

Biochem/physiol Actions

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.

Packaging

1G

Preparation Note

Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.
Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.


pictograms

FlameHealth hazard

signalword

Danger

Hazard Classifications

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

supp_hazards

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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