SMB01008
Aschantin
≥90% (LC/MS-ELSD)
Synonym(s):
(+)-Aschantin, 5-[(3S,3aR,6S,6aR)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole
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About This Item
Empirical Formula (Hill Notation):
C22H24O7
CAS Number:
Molecular Weight:
400.42
UNSPSC Code:
12352205
NACRES:
NA.25
biological source
plant
assay
≥90% (LC/MS-ELSD)
form
solid
mol wt
400.42
solubility
water: slightly soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
O1[C@@H]([C@@H]3[C@@H]([C@H](OC3)c4cc5c(cc4)OCO5)C1)c2cc(c(c(c2)OC)OC)OC
InChI
1S/C22H24O7/c1-23-18-7-13(8-19(24-2)22(18)25-3)21-15-10-26-20(14(15)9-27-21)12-4-5-16-17(6-12)29-11-28-16/h4-8,14-15,20-21H,9-11H2,1-3H3/t14-,15-,20+,21+/m0/s1
InChI key
ONDWGDNAFRAXCN-VUEDXXQZSA-N
General description
Aschantin, a bioactive lignan, is a natural product commonly available from Magnolia Sp, and Artemisia Sp. plants. This secondary metabolite derived from plant sources exhibits various biological activities such as anti-inflammatory, antioxidant, and anticancer activities.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
Aschantin has various biological activities including peroxynitrite scavenging capacity, inhibition of inducible NO synthetase, antiplasmodial activity, Ca2+-antagonistic activity, platelet activating factor-antagonistic activity, and chemo-preventative or therapeutic activity mediated via inhibition of mTOR kinase.
The anticancer activity of aschantin is achieved by inhibiting Akt, a protein that plays a crucial role in promoting cancer cell growth and proliferation. By blocking Akt, aschantin disrupts multiple signaling pathways that are essential for cancer cells to thrive and multiply. This disruption ultimately leads to the suppression of cancer cell proliferation, making it an effective strategy for combating cancer.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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