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Merck
CN

SMB01024

Diuvaretin

≥90% (LC/MS-ELSD)

Synonym(s):

1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylpropan-1-one

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About This Item

Empirical Formula (Hill Notation):
C30H28O6
CAS Number:
61463-04-5
Molecular Weight:
484.54
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
MFCD18975655

Key Documents

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SMILES string

O(C)c1c(c(c(c(c1C(=O)CCc4ccccc4)O)Cc3c(cccc3)O)O)Cc2c(cccc2)O

InChI

1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3

InChI key

KDEMELRYKGOXDL-UHFFFAOYSA-N

biological source

plant

assay

≥90% (LC/MS-ELSD)

form

solid

mol wt

484.54

solubility

water: slightly soluble

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

Related Categories

General description

Diuvaretin, a dihydrochalcone, is a natural product commonly available from Dipteryx odorata, Uvaria acuminata and Uvaria chamae plants. This plant metabolite exhibits various biological activities such as anti-inflammatory, antioxidant, antineoplastic, anti-angiogenic, and antimalarial properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Diuvaretin inhibits NF-kB activation, hindering inflammation and cancer. It also suppresses tumor cell proliferation, induces apoptosis, and diminishes tumor growth and angiogenesis in mouse cancer models.
Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial.

Features and Benefits

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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