SMB01024
Diuvaretin
≥90% (LC/MS-ELSD)
Synonym(s):
1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylpropan-1-one
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About This Item
Empirical Formula (Hill Notation):
C30H28O6
CAS Number:
Molecular Weight:
484.54
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
biological source
plant
assay
≥90% (LC/MS-ELSD)
form
solid
mol wt
484.54
solubility
water: slightly soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
O(C)c1c(c(c(c(c1C(=O)CCc4ccccc4)O)Cc3c(cccc3)O)O)Cc2c(cccc2)O
InChI
1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3
InChI key
KDEMELRYKGOXDL-UHFFFAOYSA-N
General description
Diuvaretin, a dihydrochalcone, is a natural product commonly available from Dipteryx odorata, Uvaria acuminata and Uvaria chamae plants. This plant metabolite exhibits various biological activities such as anti-inflammatory, antioxidant, antineoplastic, anti-angiogenic, and antimalarial properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
Diuvaretin inhibits NF-kB activation, hindering inflammation and cancer. It also suppresses tumor cell proliferation, induces apoptosis, and diminishes tumor growth and angiogenesis in mouse cancer models.
Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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